The 46-year-old Slovenian, who was appointed on 23 September, failed to win any of his six games in charge during his time at Elland Road.
Leeds are 18th in the Championship, five points above the relegation zone, after Saturday's 2-1 defeat by Wolves.
Neil Redfearn will again assume caretaker control of the first team for the second time this season on Monday.
Leeds owner Massimo Cellino said the former Slovenia international was a "very cool guy" when he appointed him, but his record as owner of Italian club Calgari came with a health warning for managers - he dismissed 36 managers during 22 years in charge of the Italian side.
Previous manager Dave Hockaday lasted a little longer before he was shown the door in September. That followed Brian McDermott, who was sacked in January when Cellino was poised to buy Leeds only to be reinstated a day later, only to leave the club by mutual consent in May.