An investigation into the incident, which led to a lengthy delay in the second half of the game, is on-going.
"That was the worst scene I've seen as a manager," Orient manager Russell Slade told BBC London 94.9.
The London club won the game 3-1, a result which saw them return to the top of the League One table as Wolves were held to a goalless draw by in form Brentford.
However, Slade said the incident overshadowed the match.
"It was a great win, but it was clouded by a fan running onto the pitch and throwing three punches at my goalkeeper," he said.
"It is unbelievable. He's okay, but that doesn't make it right. It's outrageous.
"He [the supporter] needs a ban for life. He should never go to another football match."