Premier League chief executive Richard Scudamore speaking about match-fixing allegations that have surfaced in the last month, said he could not rule out the possibility that match-fixing had taken place in the Premier League.
"If a person is involved in football, they shouldn't be allowed to bet on football," he told BBC Radio 5 live's Sportsweek programme.
"The time has come for that to happen."
He suggested that after talks with PFA Chief Exec, Gordon Taylor, more stringent betting rules might be applied to players and managers. At the moment they are prevented from betting on competitions they are involved in.
So for example a League 1 player could at the moment bet on a Champions League game for example.
Match-fixing and spot-fixing allegations have surfaced at various levels of the English game, from non-league football to the Championship and the fact that the most high profile so far is a former Premier League player has highlighted the need to act.
Blackburn striker DJ Campbell was one of six people questioned earlier this month - and then bailed until April 2014 - as part of a National Crime Agency (NCA) investigation into spot-fixing.
“The one thing that scares you the most about this whole industry is the idea that integrity could be impugned in any way” Scudamore said.
Scudamore added: "We have had 8,393 matches so far in the Premier League, and I can't actually sit here today and say it has never happened in those matches."
He insisted the Premier League was doing all it could to target fixers, adding: "We are monitoring over 300 international betting markets and we have a whole system of things in place."
But he admitted: "The one thing that scares you the most about this whole industry is the idea that integrity could be impugned in any way."
He said he was confident that match-fixing was not "entirely widespread and prevalent", but added that it was still a "serious issue".