To add real spice to the mix, want away Wayne Rooney has been the target of Chelsea all summer and it is a dilemma for Moyes whether to play the England star.
In fairness, Rooney came on as substitute in United's opening day win at Swansea. Moyes has been steadfast in his position on Rooney saying simply he isn't for sale.
"There is lots I've been looking forward to: taking the team on tour, leading them at Wembley," Moyes said.
"But to do it [lead the team out] at Old Trafford for the first game against Chelsea is a thrill, it really is."
Meanwhile Chelsea boss, Jose Mourhino says he can't wait for Monday's game, that could see his side open a six point gap on United if they win. United have won just once in their last six games against the Londoners.Mourinho, who won twice at United in his first spell in charge at Chelsea, said his special relationship withSir Alex Ferguson has remained strong during his six years away from England
On the Rooney issue, Mourinho, who signed a four-year deal at the London club after returning in the summer, insisted he was not interested in talking about the 27-year-old England forward.
"I don't care," he said. "In this moment I don't care. I have a big match to play on Monday. I don't care about new players."
The Portuguese says he will have enough to contend with when he takes on the the reigning Premier League champions, even though Sir Alex Ferguson is no longer at the helm.
"In my first time at Chelsea they had Roy Keane, [Paul] Scholes, players with big history there," he said. "Now they still have players from my time, like [Rio] Ferdinand, [Nemanja] Vidic, [Ryan] Giggs, and they have a mix with very good young players.
"With that winning culture, that makes the basis of big clubs. And they are a big club for many, many years. They have everything."
Betting expert, Joe Ross from www.footyinsider.co.uk told us:
'It is not often that United are a big price for a home win. The bookmakers are still not 100% convinced Moyes can follow in Sir Alex Ferguson's footsteps. History won't bother Moyes and United look a bet to us all day long.'