The rivalry between the two clubs has long been a source of bad blood between the fans and while Sir Alex Ferguson has asked fans to respect the tragedy of Hillsborough and Munich, history between the clubs suggests this will be another fierce encounter.
Last year's the Patrice Evra row with Luis Suarez added a new ugliness to the ongoing grudge match.
Liverpool have rarely been in the title race throughout the last decade as Manchester United have emerged as the top North West Club. Liverpool have just four points in four matches under Brendan Rodgers and Ferguson must fancy that United can take the spoils at Anfield on Sunday.
Outside of a respectable 2-2 draw against Man City, the Reds have looked a side that lacks goals with three in four matches.
As usual, United are gunning for the top spot early, winning three and losing once, sitting just a point behind leaders Chelsea.