Tony Scholes, City's Chief Executive, said: "This partnership continues to develop the relationship between two of the city's foremost institutions.
"While the Football Club has made great strides forward in the last few years, the University can also be proud of its progress in that time.
"As well as the important roles that both institutions play locally, we have also helped to put the area on the map both nationally and internationally, and we therefore consider there are benefits to be gained from formalising this association with the new partnership.
"An encouraging aspect of the growth of our supporter base in the past few seasons has been the increase in the number of young fans and obviously we hope that many students, whether locally based or visiting the area, will become followers of the Club in the future."
Paul Richards, the Deputy Vice Chancellor of Staffordshire University, echoed those views, saying: "This agreement formalises what has been a close association with the Football Club for some considerable time now and one which has benefited both organisations.
"We share many of the same values and I am sure we can enhance our reputations through alliance of the two brands and through working even closer together, particularly on projects which will demonstrate our commitment to transforming the lives and aspirations of the local community."
He added: "As well as the increased exposure that we will gain at Stoke City's matches, there are many business to business benefits of having a much more active link."